GCSE English Text Guide - Of Mice & Men: perfect for the 2024 and 2025 exams

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GCSE English Text Guide - Of Mice & Men: perfect for the 2024 and 2025 exams

GCSE English Text Guide - Of Mice & Men: perfect for the 2024 and 2025 exams

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If I was bright, if I was even a little bit smart, I'd have my own little place, an' I'd be bringin' in my own crops, 'stead of doin' all the work and not getting what comes up outa the ground." At Kidadl we pride ourselves on offering families original ideas to make the most of time spent together at home or out and about, wherever you are in the world. We strive to recommend the very best things that are suggested by our community and are things we would do ourselves - our aim is to be the trusted friend to parents. Sure they all want it. Everybody wants a little bit of land, not much. Jus' som'thin' that was his. Som'thin' he could live on and there couldn't nobody throw him off of it. I never had none."

What you want of a dead mouse, anyways?' 'I could pet it with my thumb while we walked along,' said Lennie.'" Bloodgood DW, Hardaway JA, Stanhope CM, Pati D, Pina MM, Neira S, et al. Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake. Mol Psychiatry. 2021;26(6):2187–99. Of Mice And Men' is one of the most important American novels as it shows the virtue of friendship, but also doesn't shy away from putting forward the futility of the idea of the American dream. Lennie seems to have a mental inability to process the world around him and George acts as a support. They both dream of owning their own ranch. As a final act of love, George took Lennie's life so he did not have to suffer at the hands of Curley, after Lennie had unwittingly killed Curly's wife. Here, we found that female mice consume more alcohol compared to their male counterparts in a modified DID paradigm across eight cycles (Figs. 1, 2), consistent with what we and others have previously shown for binge alcohol drinking models in mice [ 8, 9]. This difference was more robust for 20% compared to 10% EtOH, even though preference for alcohol over water did not differ between sexes at either alcohol concentration. Females consumed more alcohol than males across timepoints, an effect that was not dependent on overall higher fluid intake (Fig. 5). In addition, we found that protracted abstinence (2–4 weeks) from chronic binge drinking led to a behavioral disinhibition phenotype that was especially robust in females (Fig. 7). Specifically, we observed a reduction in anxiety-like and an increase in compulsive-like behavior in alcohol-abstinent females but not males compared to water control mice in the OF, NSF, and MB assays, as well as a stronger effect of alcohol experience for females in reducing avoidance behavior as measured through the EPM (Fig. 7). We additionally found basal sex differences in assays measuring reward sensitivity/anhedonia and coping behavior but no effects of alcohol abstinence in the sucrose preference, FST, and TS assays (Figs. 6, 8). Together, these results suggest that anxiety and compulsive-related behaviors are most vulnerable to pathological behavioral outcomes in protracted alcohol abstinence from chronic binge drinking, especially in females. Loneliness: The story shows the impact of loneliness and how it proves a torturing problem for a person. Lennie, due to his autistic nature, cannot live alone. Therefore, he continues to live along with George, while George also is unable to find a dependable solution or place for him. Therefore, they both try to dispel their loneliness through their friendship. Also, Curley’s wife does not see Lennie as handsome enough to cheat Curley; rather, she comes to dispel her loneliness but loses her life in her efforts to end it.

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Ford MM, Eldridge JC, Samson HH. Microanalysis of ethanol self-administration: estrous cycle phase-related changes in consumption patterns. Alcohol Clin Exp Res. 2002;26(5):635–43. Kidadl is independent and to make our service free to you the reader we are supported by advertising. i. An allusion to Golden Gloves tournament: Curley says that he got into the final of that tournament as a boxer, which is a lie. (Chapter-3)

Approximately 2.5 weeks following the last alcohol exposure, the elevated plus maze (EPM) test was conducted as previously described [ 28] in a plexiglass maze with two open and two closed arms (35 cm l × 5.5 cm w, with 15 cm h walls for closed arms) extending from a central platform (5.5 cm × 5.5 cm) elevated 50 cm above the floor. Mice were placed in the center of the EPM facing an open arm and allowed to freely explore the maze for 5 min. The percent time spent in the open arms was used to assess avoidance behavior and ambulatory locomotion was also analyzed. Due to a technical issue, EPM data for some mice could not be analyzed and were therefore excluded. Light–dark box

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In the book, 'Of Mice And Men', nature plays a role in describing the inner conflict of the characters as well as how The Great Depression played with the hopes and dreams of people. Even Lennie, at different situations, is compared to a terrier, horse, and a bear. Some of the symbolic nature quotes from the book are. I was only foolin', George. I don't want no ketchup. I wouldn't eat no ketchup if it was right here beside me.' Kimbrough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, et al. Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proc Natl Acad Sci U S A. 2020;117(4):2149–59. God, you're a lot of trouble,' said George. 'I could get along so easy and so nice if I didn't have you on my tail. I could live so easy and maybe have a girl.'" Gong MF, Wen RT, Xu Y, Pan JC, Fei N, Zhou YM, et al. Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. Psychopharmacology. 2017;234(20):3143–51.

Rivera-Irizarry JK, Skelly MJ, Pleil KE. Social isolation stress in adolescence, but not adulthood, produces hypersocial behavior in adult male and female C57BL/6J mice. Front Behav Neurosci. 2020;14:129. Eventually, George reveals the truth to Slim that Lennie is not his cousin, but they have been friends since their childhood. He also shares how Lennie created trouble, especially during their previous job. George recalls the time he was forced to flee with Lennie. Lennie had tried to touch a woman’s red dress but was accused of rape. Slim agrees to give Lennie one of his puppies. On the other hand, Carlson continues to annoy Candy to kill his old dog. Slim also agrees with Carlson’s decision. They believe death is better than letting the animal suffer. Candy is forced to agree, as well. Carlson promises to show mercy and kill the dog painlessly. Paradox: The novel shows the use of paradox in a very good sentence such as “Candy stood in the doorway scratching his bald wrist and looking blindly into the lighted room.” (Chapter-4). Here the phrase “looking blindly” shows the use of a paradox.Pang TY, Renoir T, Du X, Lawrence AJ, Hannan AJ. Depression-related behaviours displayed by female C57BL/6J mice during abstinence from chronic ethanol consumption are rescued by wheel-running. Eur J Neurosci. 2013;37(11):1803–10.



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