I started taking allithamine and got wondrous results. Faster healing, more feeling than I’ve had in ages, and my mood has improved. Has this all really just been a b1 deficiency the whole time? I practice a little of what doesn’t kill you, makes you stronger. (On this Forum I don’t want to be the cause of someone else’s death – I don’t tell all). Firstly, thank you for the work you’ve done on informing the world about Thiamine and its derivatives. Your work is outstanding and has clearly helped countless people. Not only that, your work is clearly pushing a wave forward of new “medicine” that comes from nature and is focused on true healing, not fixing symptoms. I've also been taking a B complex and good multivitamins forever, so the idea of being deficient in any vitamin was hard to imagine. I'm glad you're responding to TTFD. The article below will explain why a high diffusion is needed in case of severe thiamine deficiency. children with Down’s Syndrome, 12 of which were administered TTFD for 12 months and 12 of which were administered TTFD for 6 months. No serious adverse events noted.

Recommendation: Don’t take more than one 50mg dose. If anything try to somehow to take only half a cap for a couple days. I don’t know what it tastes like. The bottle doesn’t smell bad today (maybe because I have been taking). Since the RDA of B1 is only 1.1 mg daily, it is a shame you can’t buy a smaller dose. TTDF is water soluble. Analysis of human urine for the byproduct indicates it is 100% adsorbed. TTDF crosses the Blood Brain Barrier (thiamin HCL does not). The TFD component which is shed when entering your cells does require methylation. Both folate and vitamin B12 are the important regulators of DNA methylation . I used to eat a diet heavy in sugars and carbs and then noticed numbness forming in my fingers and toes. It took months to learn that it flares up whenever I consume any amount of sugar and even when I eat salt. I am experiencing an electrolyte imbalance (low phosphorus and potassium) after a period of fasting during Lent. I began eating normally again and experienced what I originally thought was Refeeding Syndrome. I had been diagnosed with this in the past and like this time, despite treatment and supplementing with up to 3,000 mg of Phosphorus and 160 mEq of Potassium, my blood levels are still low. I have noticed that, since increasing Lipothiamine, my nasal cycle has become more balanced and the feeling of one nostril totally plugged has receded to a further degree. This is especially true when I expend energy, like taking a walk. The response is unmistakable. I should also like to add that I speak with a stutter, and I have read that thiamine may help this condition. I have not noticed improvement in this area yet.The RDA (recommended daily allowance) for thiamine is 1.2 mg for men and 1.1 mg for women. This should be enough to avoid deficiency although how much vitamin B1 you should optimally get depends on many factors. We are trying to fix these deficiencies, but we are struggling. I started Lipothiamine 2 weeks ago, because Thiamine HCl and sublingual cocarboxylase didn’t help my B1 deficiency. It’s been a difficult start. Increased energy, slight POTS and IBS reduction; however, restlessness and anxiety has increased significantly. Also, increased pins and needles, and poor sleep. Maybe this is the paradox that is mentioned in several articles. This paradox is incredibly unpleasant and I understand why people stop treatment. I do not currently take any prescription medications although the MD’s want me to take Toprol XL and Lexapro and Progesterone cream to manage the symptoms of dysautonomia and perimenopause. I do take a large quantity of supplements. Perhaps one of the below affects thiamine absorption? Prosultiamine (TPD) at 300mg per day for 12 weeks (TPD, a very similar molecule to TTFD) used to treat spinal cord injury in human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (2013). Significant improvement in motor functions and bladder control, as well as reducing viral numbers in blood. Only adverse symptom was mild epigastric discomfort. No safety concerns.

children with pneumonia treated using TTFD as primary treatment (10mg IM <3 months old, 20mg IM <6 months, 20mg twice per day >6 months old) I performed animal and clinical studies with thiamine tetrahydrofurfuryl (TTFD) for many years and found it to be an extremely valuable therapeutic nutrient. Any disease where energy deficiency is the underlying cause may respond to TTFD, unless permanent damage has accrued. Dr. Marrs and I believe that energy deficiency applies to any naturally occurring disease, even when a gene is at fault. For example, Japanese investigators found that TTFD protected mice from cyanide and carbon tetrachloride poisoning, an effect that was not shown by ordinary thiamine (Fujiwara, M. Absorption, excretion and fatal thiamine and its derivatives in the human body. In Shimazono, N, Katsura, E, eds. Beriberi and Thiamine. (pp 120-121) Tokyo, Igaku Shoin Ltd. 1965). They exposed a segment of dog’s intestine, disconnected it from its nerve supply and found that one of the disulfide derivatives stimulated peristalsis (the wavelike movement of the intestine). It is more than likely that TTFD could be used safely in patients with post operative paralysis of the intestine (paralytic ileus). Other Derivatives If thats true, that Allithiamine or Thiamax would be as effective or almost as effective as enterically coated TTFD would that also be the case if I had some form of WE if whatever I have was caused by alcohol or if there was an alcohol history ? My understanding although I could be wrong , is that if issues have been induced by alcohol then things change in terms of treatment course and prognosis. Any light you could shed on this would be greatly appreciated.. Thanking you in advance for your time and help.A similar chemical, also a thiamine open-ring disulfide derivative, sulbutiamine, is available as a powder through several online venders (like Nootropics Depot, to name one). I don’t know what the equivalent dosage to TTFD would be, however. Is there a “mini” paradox associated with the raising of the dose? Perhaps I notice 1-2 days of such symptoms when I have increased. I would love to know what caused my health problems, but my tests have mostly been normal except for Graves’ disease. Even my genome looks okay, with no problems on the thiamine or cobalamin transporter genes. It makes me a bit uneasy to keep my B12 level so high, so I’d really like to understand why I need it. Update Day 5… other things are stressful in my life (It’s not just that my PD was getting worst, which was very depressing). Diabetic lactic acidosis – 100mg/day IV for 7 days resolution in symptoms, followed by 75mg indefinitely (2008)